Disruption of nicotine conditioning by dopamine D3 receptor ligands

P139: Role of Dopamine Receptor D3 in Depression and Anxiety

Dopamine (DA) is one of the main catecholamines in the brain and is crucial for movement coordination, endocrine function, reward, mood, memory and emotions. The dopaminergic system is the primary therapeutic target in the treatment of Parkinson’s disease (PD), drug addiction and schizophrenia. Notwithstanding, dysfunction of central dopaminergic neurotransmission has also been associated to de...

GPCR targeted library design: novel dopamine D3 receptor ligands.

p139: role of dopamine receptor d3 in depression and anxiety

dopamine (da) is one of the main catecholamines in the brain and is crucial for movement coordination, endocrine function, reward, mood, memory and emotions. the dopaminergic system is the primary therapeutic target in the treatment of parkinson’s disease (pd), drug addiction and schizophrenia. notwithstanding, dysfunction of central dopaminergic neurotransmission has also been associated to de...

Enhancement of ethanol reward by dopamine D3 receptor blockade.

This experiment examined the influence of U-99194A, a dopamine D3 receptor antagonist, on ethanol's rewarding effect in a place conditioning paradigm. Swiss-Webster mice received six pairings of a tactile stimulus with ethanol (2 g/kg, i.p.), U-99194A (20 mg/kg, i. p.) with ethanol, or U-99194A alone. A different stimulus was paired with saline. During conditioning, ethanol or ethanol/U-99194A ...

Synthesis, Molecular Properties Estimations, and Dual Dopamine D2 and D3 Receptor Activities of Benzothiazole-Based Ligands

Neurleptic drugs, e.g., aripiprazole, targeting the dopamine D2S and D3 receptors (D2SR and D3R) in the central nervous system are widely used in the treatment of several psychotic and neurodegenerative diseases. Therefore, a new series of benzothiazole-based ligands (3-20) was synthesized by applying the bioisosteric approach derived from the selective D3Rs ligand BP-897 (1) and its structural...